FIONA on Caenorhabditis elegans
نویسندگان
چکیده
منابع مشابه
FIONA on Caenorhabditis elegans.
Despite much work, subcellular neurons of Caenorhabditis elegans have not been studied at nanometer resolution with millisecond time resolution. Nor has there been an effective way to immobilize C. elegans. Here we show that, without using anesthetic or paralyzing agents, fluorescence imaging with one-nanometer accuracy (FIONA) can be successfully applied to fluorescently labeled molecules with...
متن کاملCaenorhabditis Elegans
Transparent, free-living nematode worm. Unsegmented body plan with full set of differentiated tissues (neural, endoderm, ectoderm and muscle). Genome size approximately 97 Mb, as five autosomes and one X sex chromosome. Fully sequenced genome, which comprises approximately 20 000 predicted genes. Defined cell lineage. Has made major contribution to studies of development, cell-to-cell signallin...
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The complete structure of the anterior sensory nervous system of the small nematode C . elegans has been determined by reconstruction from serial section electronmicrographs. There are 58 neurons in the tip of the head. Fiftytwo of these are arranged in sensilla. These include six inner labial sensilla, six outer labial sensilla, four cephalic sensilla and two amphids. Each sensillum consists o...
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MOTIVATION Caenorhabditis elegans, a roundworm found in soil, is a widely studied model organism with about 1000 cells in the adult. Producing high-resolution fluorescence images of C.elegans to reveal biological insights is becoming routine, motivating the development of advanced computational tools for analyzing the resulting image stacks. For example, worm bodies usually curve significantly ...
متن کاملNeurogenetics, in Caenorhabditis elegans
The human brain is an extraordinarily complex and beautiful organ. It has one hundred billion neurons and an inestimable number of synaptic connections. Since there are very few opportunities to ethically test experimental hypotheses on the human brain, we rely on model organisms to understand how neurons work in humans. Such an organism, the nematode Caenorhabditis elegans, with a total of onl...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi8023477